Pierre-Emerick Aubameyang has scored in his last four PL London derbies, netting six goals and adding two assists.
Mohamed Salah has scored twice and assisted two more goals in his three PL appearances against Brighton.
Chris Wood has scored three times in five appearances against the Cottagers in all competitions and goes into this meeting with goals in his last two PL matches.
Angus Gunn could become the first Southampton goalkeeper to keep a clean sheet in his first two PL appearances.
Eden Hazard has scored six goals and assisted one in five PL appearances against Newcastle at Stamford Bridge.
Salomon Rondon has scored Newcastle’s last three PL away goals.
Ryan Fraser has provided nine PL assists this season, the joint-highest number, and could become the first Scottish player to reach double figures in a campaign.
David Silva is in line to make his 267th PL appearance, which would be more than any other City player in the competition’s history.