The home team have won just three of the last 15 Premier League meetings between these sides (W3 D5 L7).
There have been seven goals from direct free-kicks in PL fixtures between these teams, including two by Southampton last season. There have only been more in total in matches between Liverpool and Man Utd, with eight.
In all competitions, Man Utd have won more away matches at St Mary's against Southampton than any other side, with 10 victories.
Chelsea have lost only three of their 80 Premier League home matches against promoted teams (W66 D11 L3) and have never lost such a fixture in August (W10 D1 L0).
Out of their last 22 top-flight matches in London, both of Sheffield United's wins have come at Chelsea.
The Blades are looking for their first victory at Chelsea since October 1992, when they won their first PL visit there 2-1 with goals from Adrian Littlejohn and Brian Deane.
Palace have won 10 Premier League matches in 2019. Only Manchester City, Liverpool and Arsenal have had more victories, with 19, 16 and 12 respectively.
Roy Hodgson has won more PL matches against Aston Villa than against any other side (P11 W7 D2 L2). He has also won his first meeting with them with his previous four clubs in the competition, at Blackburn Rovers, Fulham, Liverpool and West Bromwich Albion.
Villa will be looking to win consecutive PL matches for the first time since May 2015, when they beat Everton and West Ham under Tim Sherwood.
Leicester are unbeaten in their last six home league matches against AFC Bournemouth (W3 D3 L0), last losing in December 1988 at Filbert Street.
AFC Bournemouth have only lost one of their eight PL matches against Leicester (W2 D5 L1), although that defeat came in their most recent meeting in March.
The Cherries have won three of their last six PL away matches (D1 L2), having lost the previous nine in a row. They have netted 15 goals in those six encounters, as many as in their previous 15 on the road.
Man City have won their last five matches against Brighton in all competitions, winning all four league games in the past two seasons and an FA Cup semi-final in April this year.
Only one of Pep Guardiola's 32 top-flight defeats as a manager has come against an English manager. He lost to Roy Hodgson's Crystal Palace at the Etihad Stadium last December.
Brighton are seeking their first league win at Man City at the 10th attempt.
Newcastle were unbeaten in their Premier League meetings with Watford last term, winning one match and drawing the other, having lost all four of the fixtures across the 2015/16 and 2017/18 seasons.
This will be Steve Bruce's first PL meeting with Watford. He last faced them in the Championship in April 2013, falling to a 1-0 defeat with Hull City.
Watford have won three of their last four matches at Newcastle in all competitions, after winning just two of their first 17 visits there.
West Ham are unbeaten in their last seven home league matches against Norwich, since a 2-0 defeat at Upton Park in March 1989.
The Hammers have won four of their last six Premier League matches, as many as they had won in their previous 16.
Norwich have converted six of their 33 PL shots so far this season, giving them the best conversion rate in the division, with 18 per cent.
The Canaries are seeking their first victory in London in seven years, having last won 2-1 in the capital against Tottenham Hotspur under Paul Lambert.
A win for Liverpool would set a club record of 13 consecutive league victories, beating the 12 set by Kenny Dalglish’s side in October 1990.
Liverpool are unbeaten in 20 Premier League matches (W16 D4 L0) and have lost only one of their last 42 in the competition, a 2-1 defeat by Manchester City in January.
Wolves are looking for a second successive top-flight victory over Everton for the first time since September 1979.
Since the start of last season, no side have gained more points from losing positions in the Premier League than Wolves (16, level with Liverpool). They have come from behind to salvage a point in their last two league matches.
Everton are targeting a seventh straight PL clean sheet at home and their best run since 2013.
Arsenal have won more Premier League matches, with 60, and have a higher win rate, with 61 per cent, than any other side in September. They are also unbeaten in September north London derbies in all competitions since 1969, winning six and drawing four.
Five of the last 14 goals scored in PL matches between these teams have been penalties. In total, 18 spot-kicks have been scored in their PL meetings, the joint-most of any duel alongside Everton v Newcastle United.
Arsenal have not lost against Spurs at Home since nov 2010, winning 5 & drawing 3
Watford have conceded in each of their last 15 Premier League games, shipping 32 goals in total.